Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Defecto en la homeostasis del oxido nítrico. Mecanismo común subyacente de la insulino-resistencia, la hiperactividad simpática y la morbi-mortalidad cardiovascular [Defective nitric oxide homeostasis. Common underlying mechanism between insulin resistance, sympathetic overactivity and cardiovascular morbidity and mortality]
Publication types: English Abstract ; Journal Article ; Review
Obesity, insulin resistance and associated cardiovascular complications are reaching epidemic proportions worldwide and represent a major public health problem. Over the past decade, evidence has accumulated indicating that insulin administration, in addition to its metabolic effects, also has important cardiovascular actions. The sympathetic nervous system and the L-arginine-nitric oxide pathway are the central players in the mediation of insulin's cardiovascular actions. Based on recent animal and human research, we demonstrate that both defective and augmented NO synthesis represent a central defect triggering many of the metabolic, vascular and sympathetic abnormalities characteristic of insulin-resistant states. These observations provide the rationale for the use of pharmaceutical drugs releasing small and physiological amounts of NO and/or inhibitors of NO overproduction as a future treatment for insulin resistance and associated comorbidities.
Animals, Biological Availability, Cardiovascular Diseases/etiology, Cardiovascular Diseases/physiopathology, Endothelium, Vascular/drug effects, Endothelium, Vascular/metabolism, Homeostasis, Humans, Hypertension/etiology, Hypertension/physiopathology, Hypoglycemic Agents/pharmacology, Insulin/pharmacology, Insulin Resistance/physiology, Nitric Oxide/biosynthesis, Nitric Oxide/deficiency, Nitric Oxide Donors/pharmacology, Nitric Oxide Synthase Type I/metabolism, Nitric Oxide Synthase Type II/metabolism, Nitric Oxide Synthase Type III/metabolism, Rats, Sympathetic Nervous System/drug effects, Sympathetic Nervous System/physiopathology
Web of science
Last modification date