Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus.

Détails

ID Serval
serval:BIB_8A25A981E53A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus.
Périodique
Nature
Auteur(s)
Acha-Orbea H., Shakhov A.N., Scarpellino L., Kolb E., Müller V., Vessaz-Shaw A., Fuchs R., Blöchlinger K., Rollini P., Billotte J., Sarafidou M., MacDonald H.R., Diggelmann H.
ISSN
0028-0836 (Print)
ISSN-L
0028-0836
Statut éditorial
Publié
Date de publication
1991
Volume
350
Numéro
6315
Pages
207-211
Langue
anglais
Résumé
Autoreactive T lymphocytes are clonally deleted during maturation in the thymus. Deletion of T cells expressing particular receptor V beta elements is controlled by poorly defined autosomal dominant genes. A gene has now been identified by expression of transgenes in mice which causes deletion of V beta 14+ T cells. The gene lies in the open reading frame of the long terminal repeat of the mouse mammary tumour virus.
Mots-clé
Amino Acid Sequence, Animals, Chromosome Deletion, Electrophoresis, Polyacrylamide Gel, Female, Genes, Viral, Mammary Tumor Virus, Mouse/genetics, Mice, Mice, Transgenic, Molecular Sequence Data, Open Reading Frames, Phenotype, Proviruses/genetics, Receptors, Antigen, T-Cell/genetics, T-Lymphocytes/immunology
Pubmed
Web of science
Création de la notice
24/01/2008 15:48
Dernière modification de la notice
03/03/2018 19:09
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