Article: article from journal or magazin.
Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus.
Autoreactive T lymphocytes are clonally deleted during maturation in the thymus. Deletion of T cells expressing particular receptor V beta elements is controlled by poorly defined autosomal dominant genes. A gene has now been identified by expression of transgenes in mice which causes deletion of V beta 14+ T cells. The gene lies in the open reading frame of the long terminal repeat of the mouse mammary tumour virus.
Amino Acid Sequence, Animals, Chromosome Deletion, Electrophoresis, Polyacrylamide Gel, Female, Genes, Viral, Mammary Tumor Virus, Mouse/genetics, Mice, Mice, Transgenic, Molecular Sequence Data, Open Reading Frames, Phenotype, Proviruses/genetics, Receptors, Antigen, T-Cell/genetics, T-Lymphocytes/immunology
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