Brain gray matter volume associations with gait speed and related structural covariance networks in cognitively healthy individuals and in patients with mild cognitive impairment: A cross-sectional study.
Details
Serval ID
serval:BIB_8A1449F8D0A9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Brain gray matter volume associations with gait speed and related structural covariance networks in cognitively healthy individuals and in patients with mild cognitive impairment: A cross-sectional study.
Journal
Experimental gerontology
Working group(s)
Canadian Gait Consortium
ISSN
1873-6815 (Electronic)
ISSN-L
0531-5565
Publication state
Published
Issued date
15/07/2019
Peer-reviewed
Oui
Volume
122
Pages
116-122
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Gait speed is slower in patients with mild cognitive impairment (MCI) compared to cognitively healthy individuals (CHI). We examined the patterns of brain gray matter (GM) volume association and covariance with gait speed in CHI and in patients with MCI.
A total of 96 CHI and 99 patients with MCI were recruited in this cross-sectional study. Brain GM volumes measured with voxel-based morphometry and self-paced gait speed were used as outcomes.
The right middle frontal and precentral gyri volumes were positively associated with gait speed in CHI and covariated with frontal cortex. Striatum (i.e. left putamen and bilateral caudate nuclei) volumes were positively associated with gait speed in patients with MCI and covariated with striatal structures.
Two different patterns of brain GM volume association and covariance with gait speed were found and involving frontal cortex in CHI and the striatum in patients with MCI.
A total of 96 CHI and 99 patients with MCI were recruited in this cross-sectional study. Brain GM volumes measured with voxel-based morphometry and self-paced gait speed were used as outcomes.
The right middle frontal and precentral gyri volumes were positively associated with gait speed in CHI and covariated with frontal cortex. Striatum (i.e. left putamen and bilateral caudate nuclei) volumes were positively associated with gait speed in patients with MCI and covariated with striatal structures.
Two different patterns of brain GM volume association and covariance with gait speed were found and involving frontal cortex in CHI and the striatum in patients with MCI.
Keywords
Aged, Brain Mapping/methods, Cognitive Dysfunction/diagnostic imaging, Cognitive Dysfunction/physiopathology, Cross-Sectional Studies, Female, Gait, Gray Matter/diagnostic imaging, Gray Matter/physiopathology, Humans, Image Interpretation, Computer-Assisted, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Organ Size, Software, Walking Speed, Cognitive disorders, Gait speed, MRI, Motor control
Pubmed
Web of science
Create date
04/10/2023 22:43
Last modification date
05/10/2023 6:59
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