Antimicrobial peptides and self-DNA in autoimmune skin inflammation.

Détails

ID Serval
serval:BIB_89F88FEB884B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Antimicrobial peptides and self-DNA in autoimmune skin inflammation.
Périodique
Current Opinion in Immunology
Auteur(s)
Gilliet M., Lande R.
ISSN
0952-7915 (Print)
ISSN-L
0952-7915
Statut éditorial
Publié
Date de publication
2008
Volume
20
Numéro
4
Pages
401-407
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Toll-like receptor (TLR)-mediated detection of viral nucleic acids and production of type I interferons (IFNs) by plasmacytoid dendritic cells (pDCs) are key elements of antiviral defense. By contrast, inappropriate recognition of self-nucleic acids with induction of IFN responses in pDCs can lead to autoimmunity. In this review we describe how pDC responses to self-DNA are normally avoided and focus on our recent finding that in psoriasis, a common autoimmune disease of the skin, these barriers can be breached by the cationic antimicrobial peptide LL37. LL37 binds extracellular self-DNA fragments into aggregated particles that enter pDCs and trigger robust IFN responses by activating endosomal TLR9 as if they were viruses. We also describe the mechanisms that normally control production and activity of LL37 in human skin and propose that the persistent overexpression of LL37 in psoriasis leads to uncontrolled IFN responses that drive autoimmune skin inflammation.
Mots-clé
Antimicrobial Cationic Peptides/immunology, Antimicrobial Cationic Peptides/metabolism, Autoimmune Diseases/immunology, Autoimmune Diseases/metabolism, Autoimmunity, Cathelicidins, DNA/immunology, DNA/metabolism, DNA, Viral/immunology, DNA, Viral/metabolism, Dendritic Cells/immunology, Dendritic Cells/metabolism, Deoxyribose/immunology, Deoxyribose/metabolism, Humans, Inflammation/immunology, Inflammation/metabolism, Interferon Type I/immunology, Interferon Type I/metabolism, Psoriasis/immunology, Psoriasis/metabolism, Self Tolerance, Skin/immunology, Skin/metabolism, Toll-Like Receptor 9/immunology, Toll-Like Receptor 9/metabolism
Pubmed
Web of science
Création de la notice
23/03/2012 12:54
Dernière modification de la notice
03/03/2018 19:08
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