The murine interleukin-2 receptor gamma chain gene: organization, chromosomal localization and expression in the adult thymus.

Détails

ID Serval
serval:BIB_89E78957E187
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The murine interleukin-2 receptor gamma chain gene: organization, chromosomal localization and expression in the adult thymus.
Périodique
European Journal of Immunology
Auteur(s)
DiSanto J.P., Certain S., Wilson A., MacDonald H.R., Avner P., Fischer A., de Saint Basile G.
ISSN
0014-2980 (Print)
ISSN-L
0014-2980
Statut éditorial
Publié
Date de publication
1994
Volume
24
Numéro
12
Pages
3014-3018
Langue
anglais
Résumé
Defects in the interleukin-2 receptor gamma (IL-2R gamma) chain in the man result in an X-linked severe combined immunodeficiency, SCIDX1, characterized by an absence of T-cell differentiation. This phenotype may result from pertubations in IL-2, IL-4-, IL-7- or IL-15-mediated signaling, as the IL-2R gamma chain forms an integral component of these receptor systems. We have isolated and characterized cDNA and genomic clones for the murine IL-2R gamma. The gene (Il2rg) is well conserved between mouse and man with respect to overall structure and size, and contains regions of high conservation in the promoter region as well. Il2rg maps to mouse X chromosome region 40, in a region of synteny with human Xq12-13.1. We have also explored the expression of the IL-2R gamma during thymocyte development. IL-2R gamma transcripts are detected in the earliest thymocyte precursor cells and persist throughout intrathymic development into the mature peripheral compartment. Genomic clones for the murine IL-2R gamma will allow for further studies on the regulation and function of this gene in vivo.
Mots-clé
Amino Acid Sequence, Animals, Base Sequence, Chromosome Mapping, Consensus Sequence, DNA, Complementary/genetics, Gene Expression, Genes, Mice, Molecular Sequence Data, Promoter Regions, Genetic, RNA, Messenger/genetics, Receptors, Interleukin-2/genetics, Restriction Mapping, Sequence Alignment, Sequence Homology, Nucleic Acid, Thymus Gland/physiology
Pubmed
Web of science
Création de la notice
11/04/2013 11:50
Dernière modification de la notice
03/03/2018 19:08
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