Evolution of white matter tract microstructure across the life span.

Détails

ID Serval
serval:BIB_89DBF4956A87
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Evolution of white matter tract microstructure across the life span.
Périodique
Human brain mapping
Auteur(s)
Slater D.A., Melie-Garcia L., Preisig M., Kherif F., Lutti A., Draganski B.
ISSN
1097-0193 (Electronic)
ISSN-L
1065-9471
Statut éditorial
Publié
Date de publication
05/2019
Peer-reviewed
Oui
Volume
40
Numéro
7
Pages
2252-2268
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The human brain undergoes dramatic structural change over the life span. In a large imaging cohort of 801 individuals aged 7-84 years, we applied quantitative relaxometry and diffusion microstructure imaging in combination with diffusion tractography to investigate tissue property dynamics across the human life span. Significant nonlinear aging effects were consistently observed across tracts and tissue measures. The age at which white matter (WM) fascicles attain peak maturation varies substantially across tissue measurements and tracts. These observations of heterochronicity and spatial heterogeneity of tract maturation highlight the importance of using multiple tissue measurements to investigate each region of the WM. Our data further provide additional quantitative evidence in support of the last-in-first-out retrogenesis hypothesis of aging, demonstrating a strong correlational relationship between peak maturational timing and the extent of quadratic measurement differences across the life span for the most myelin sensitive measures. These findings present an important baseline from which to assess divergence from normative aging trends in developmental and degenerative disorders, and to further investigate the mechanisms connecting WM microstructure to cognition.
Mots-clé
MRI, aging, degeneration, development, intracellular volume fraction (ICVF), iron, life span, longitudinal (R1) and transverse (R2*) relaxation rates, mean diffusivity (MD), myelin, quantitative magnetic resonance imaging (qMRI), tractography, white matter
Pubmed
Web of science
Création de la notice
31/01/2019 10:19
Dernière modification de la notice
20/08/2019 15:48
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