Activation of regional cerebral blood flow by a memorization task in early Parkinson's disease patients and normal subjects.

Détails

ID Serval
serval:BIB_89D7AA8A6B46
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Activation of regional cerebral blood flow by a memorization task in early Parkinson's disease patients and normal subjects.
Périodique
Journal of Cerebral Blood Flow and Metabolism
Auteur(s)
Démonet J.F., Celsis P., Agniel A., Cardebat D., Rascol O., Marc-Vergnes J.P.
ISSN
0271-678X (Print)
ISSN-L
0271-678X
Statut éditorial
Publié
Date de publication
1994
Peer-reviewed
Oui
Volume
14
Numéro
3
Pages
431-438
Langue
anglais
Notes
Publication types: Comparative Study ; Journal ArticlePublication Status: ppublish
Résumé
Task-induced changes in regional cerebral blood flow (rCBF) during memory activation were compared in 18 right-handed patients with early Parkinson's disease (PD) and 20 normal volunteers using the same activation paradigm. We used single-photon emission computed tomography and 133Xe in 21 regions of interest during rest, passive listening of a work list, and memorization of another word list, which was followed by a free recall test immediately after completion of the rCBF measurement. The average performance on free recall was not significantly lower in PD patients than in controls. In normal subjects, five left-sided regions (anterior middle frontal, posterior inferior frontal, superior middle temporal, thalamic, and lenticular) showed a significant increase in memorizing compared to passive listening. This pattern of activation suggests the existence of a verbal rehearsal strategy during the memorization task in normals. In PD patients, increases in these regions did not reach significance, whereas significant activations were noted in superior prefrontal regions. Such alterations in the pattern of activation in PD patients, despite a memory performance similar to that of controls are viewed as a consequence of an early dysfunction of the articulatory loop system and of compensatory mechanisms in other parts of the frontal lobe emerging in the early stages of the disease.
Mots-clé
Aged, Analysis of Variance, Brain/radionuclide imaging, Cerebrovascular Circulation, Female, Humans, Male, Memory/physiology, Mental Recall/physiology, Middle Aged, Parkinson Disease/physiopathology, Reference Values, Tomography, Emission-Computed, Single-Photon
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/03/2013 16:23
Dernière modification de la notice
08/05/2019 21:37
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