Biological impact assessment of nanomaterial used in nanomedicine. introduction to the NanoTEST project.

Détails

ID Serval
serval:BIB_89CA2689005C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Biological impact assessment of nanomaterial used in nanomedicine. introduction to the NanoTEST project.
Périodique
Nanotoxicology
Auteur(s)
Juillerat-Jeanneret L., Dusinska M., Fjellsbø L.M., Collins A.R., Handy R.D., Riediker Michael
Collaborateur(s)
NanoTEST Consortium
ISSN
1743-5404 (Electronic)
ISSN-L
1743-5390
Statut éditorial
Publié
Date de publication
05/2015
Peer-reviewed
Oui
Volume
9 Suppl 1
Pages
5-12
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Therapeutic nanoparticles (NPs) are used in nanomedicine as drug carriers or imaging agents, providing increased selectivity/specificity for diseased tissues. The first NPs in nanomedicine were developed for increasing the efficacy of known drugs displaying dose-limiting toxicity and poor bioavailability and for enhancing disease detection. Nanotechnologies have gained much interest owing to their huge potential for applications in industry and medicine. It is necessary to ensure and control the biocompatibility of the components of therapeutic NPs to guarantee that intrinsic toxicity does not overtake the benefits. In addition to monitoring their toxicity in vitro, in vivo and in silico, it is also necessary to understand their distribution in the human body, their biodegradation and excretion routes and dispersion in the environment. Therefore, a deep understanding of their interactions with living tissues and of their possible effects in the human (and animal) body is required for the safe use of nanoparticulate formulations. Obtaining this information was the main aim of the NanoTEST project, and the goals of the reports collected together in this special issue are to summarise the observations and results obtained by the participating research teams and to provide methodological tools for evaluating the biological impact of NPs.

Mots-clé
Humans, Materials Testing/methods, Nanomedicine/methods, Nanoparticles/toxicity, Nanostructures/toxicity, Nanoparticles, biocompatibility, risk assessment, therapeutic nanomaterials
Pubmed
Web of science
Création de la notice
29/07/2013 11:38
Dernière modification de la notice
08/11/2018 12:21
Données d'usage