Human Oligodendrocytes and Myelin In Vitro to Evaluate Developmental Neurotoxicity.

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State: Public
Version: author
License: CC BY 4.0
Serval ID
serval:BIB_899FF5FD34ED
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Human Oligodendrocytes and Myelin In Vitro to Evaluate Developmental Neurotoxicity.
Journal
International journal of molecular sciences
Author(s)
Chesnut M., Hartung T., Hogberg H., Pamies D.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Publication state
Published
Issued date
25/07/2021
Peer-reviewed
Oui
Volume
22
Number
15
Pages
7929
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Neurodevelopment is uniquely sensitive to toxic insults and there are concerns that environmental chemicals are contributing to widespread subclinical developmental neurotoxicity (DNT). Increased DNT evaluation is needed due to the lack of such information for most chemicals in common use, but in vivo studies recommended in regulatory guidelines are not practical for the large-scale screening of potential DNT chemicals. It is widely acknowledged that developmental neurotoxicity is a consequence of disruptions to basic processes in neurodevelopment and that testing strategies using human cell-based in vitro systems that mimic these processes could aid in prioritizing chemicals with DNT potential. Myelination is a fundamental process in neurodevelopment that should be included in a DNT testing strategy, but there are very few in vitro models of myelination. Thus, there is a need to establish an in vitro myelination assay for DNT. Here, we summarize the routes of myelin toxicity and the known models to study this particular endpoint.
Keywords
developmental diseases, developmental neurotoxicity, myelin, neurotoxicity, oligodendrocytes, organoid, organotypic
Pubmed
Web of science
Open Access
Yes
Create date
20/08/2021 15:47
Last modification date
23/02/2022 6:36
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