Corticosteroid-responsive postmalaria encephalopathy characterized by motor aphasia, myoclonus, and postural tremor

Détails

ID Serval
serval:BIB_8990CEBB1BD8
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Corticosteroid-responsive postmalaria encephalopathy characterized by motor aphasia, myoclonus, and postural tremor
Périodique
Archives of Neurology
Auteur(s)
Schnorf  H., Diserens  K., Schnyder  H., Chofflon  M., Loutan  L., Chaves  V., Landis  T.
ISSN
0003-9942 (Print)
Statut éditorial
Publié
Date de publication
03/1998
Volume
55
Numéro
3
Pages
417-20
Notes
Case Reports
Journal Article --- Old month value: Mar
Résumé
OBJECTIVES: To study the clinical spectrum of an acute severe encephalopathy occurring in 2 patients after recovery from falciparum malaria infection and to compare it with the reported clinical features of the postmalaria neurological syndrome. DESIGN: Case report. SETTING: Tertiary care hospital. PATIENTS: Two patients presented with acute onset of fluctuating motor aphasia, severe generalized myoclonus, and postural tremor. Additional signs were cerebellar ataxia, and in 1 patient, generalized epileptic seizures. Magnetic resonance imaging of the brain revealed patchy white matter lesions in 1 patient. Clinically, the patients' conditions continued to worsen until corticosteroids were introduced, the use of which induced a rapid, albeit incomplete, recovery. CONCLUSIONS: We describe a new, severe variant of the still poorly defined postmalaria neurological syndrome. We propose a preliminary classification of this syndrome, according to its clinical characteristics, as follows: a mild or localized form, characterized by isolated cerebellar ataxia or postural tremor; a diffuse, but relatively mild encephalopathic form, characterized by acute confusion or epileptic seizures; and a severe, corticosteroid-responsive encephalopathy that is characterized by motor aphasia, generalized myoclonus, postural tremor, and cerebellar ataxia.
Mots-clé
Adrenal Cortex Hormones/administration & dosage Adult Aphasia/*etiology Female Humans Malaria, Cerebral/*complications/drug therapy Male Middle Aged Myoclonus/*etiology Posture Tremor/*etiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 12:42
Dernière modification de la notice
20/08/2019 15:48
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