A randomised controlled trial of placebo, droperidol or ondansetron to prevent nausea and vomiting after tonsillectomy in children receiving dexamethasone.

Détails

ID Serval
serval:BIB_8988DF70AD22
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A randomised controlled trial of placebo, droperidol or ondansetron to prevent nausea and vomiting after tonsillectomy in children receiving dexamethasone.
Périodique
Anaesthesia
Auteur(s)
Flubacher P., Fournier N., Cherpillod J., Waridel F., Nydegger M., Albrecht E.
ISSN
1365-2044 (Electronic)
ISSN-L
0003-2409
Statut éditorial
Publié
Date de publication
07/2017
Peer-reviewed
Oui
Volume
72
Numéro
7
Pages
859-863
Langue
anglais
Notes
Publication types: Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Résumé
We tested whether prophylactic droperidol and ondansetron, in combination with a moderate dose of dexamethasone, were equally effective in reducing nausea and vomiting after tonsillectomy in children and that both were superior to saline with dexamethasone. We randomly allocated 300 children to intravenous saline, droperidol 10 μg.kg <sup>-1</sup> or ondansetron 150 μg.kg <sup>-1</sup> , after induction of anaesthesia and the administration of intravenous dexamethasone 250 μg.kg <sup>-1</sup> . The rates (95%CI) of nausea or vomiting within 24 postoperative hours were: 42/91 after saline, 46% (36%-57%); 43/87 after droperidol, 49% (39%-60%); reduced to 18/84 by ondansetron, 21% (13%-32%), p < 0.001. There were no differences in the rates of side-effects between groups. We conclude that ondansetron is more effective than saline in preventing nausea or vomiting after paediatric tonsillectomy when given with a moderate dose of dexamethasone, whereas droperidol was not.
Mots-clé
Antiemetics/therapeutic use, Child, Child, Preschool, Dexamethasone/therapeutic use, Double-Blind Method, Droperidol/adverse effects, Droperidol/therapeutic use, Female, Humans, Male, Ondansetron/adverse effects, Ondansetron/therapeutic use, Postoperative Nausea and Vomiting/prevention & control, Tonsillectomy, PONV: after paediatric surgery, PONV: prophylaxis, steroid prophylaxis: indications
Pubmed
Web of science
Création de la notice
09/05/2017 18:56
Dernière modification de la notice
20/08/2019 15:48
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