Vitamins and carotenoids in human milk delivering preterm and term infants: Implications for preterm nutrient requirements and human milk fortification strategies.

Details

Serval ID
serval:BIB_89880A60EA7B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Vitamins and carotenoids in human milk delivering preterm and term infants: Implications for preterm nutrient requirements and human milk fortification strategies.
Journal
Clinical nutrition
Author(s)
Redeuil K., Lévêques A., Oberson J.M., Bénet S., Tissot E., Longet K., de Castro A., Romagny C., Beauport L., Fischer Fumeaux C.J., Tolsa J.F., Affolter M., Giménez E.C., Garcia-Rodenas C.L., Thakkar S.K.
ISSN
1532-1983 (Electronic)
ISSN-L
0261-5614
Publication state
Published
Issued date
01/2021
Peer-reviewed
Oui
Volume
40
Number
1
Pages
222-228
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Differences in vitamin and carotenoids content of human milk (HM) produced for infants born at term and preterm is poorly understood. In this study, HM was collected weekly for four and two months post-partum for preterm and term groups, respectively. Nutrients of interest, from single full breast expressions were measured by liquid chromatography coupled with mass spectrometry. Microbiological assay was employed for vitamin B <sub>12</sub> . When compared at equivalent post-partum age, vitamins B <sub>1</sub> , B <sub>2</sub> , B <sub>6</sub> , and B <sub>9</sub> were significantly higher in preterm than in term HM, but only during the first two weeks. No significant differences were observed for A, E, B <sub>3</sub> and B <sub>12</sub> between groups. Lycopene was the only carotenoid exhibiting a significant higher concentration in term than in preterm HM between weeks 1 and 4 post-partum. When compared at equivalent post-menstrual age, preterm milk was significantly higher for vitamins B <sub>1</sub> , B <sub>2</sub> , B <sub>3</sub> , B <sub>6</sub> and B <sub>9</sub> and lower levels of vitamins A, E, β-carotene, β-cryptoxanthin, lutein, zeaxanthin and lycopene compared to their term counterparts. These results suggest that preterm breastfed infants at term equivalent age may receive lower amounts of these micronutrients than breast-fed term neonates, possibly highlighting the need to supplement or fortify their nutritional intake with vitamins and carotenoids. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT #02052245.
Keywords
Human milk, Longitudinal, Nutrients, Preterm, Term, Vitamins
Pubmed
Web of science
Create date
25/06/2020 14:35
Last modification date
22/01/2021 6:26
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