Article: article from journal or magazin.
Two GacA-dependent small RNAs modulate the quorum-sensing response in Pseudomonas aeruginosa.
Journal of Bacteriology
In Pseudomonas aeruginosa, the GacS/GacA two-component system positively controls the quorum-sensing machinery and the expression of extracellular products via two small regulatory RNAs, RsmY and RsmZ. An rsmY rsmZ double mutant and a gacA mutant were similarly impaired in the synthesis of the quorum-sensing signal N-butanoyl-homoserine lactone, the disulfide bond-forming enzyme DsbA, and the exoproducts hydrogen cyanide, pyocyanin, elastase, chitinase (ChiC), and chitin-binding protein (CbpD). Both mutants showed increased swarming ability, azurin release, and early biofilm development.
Bacterial Proteins/metabolism, Biofilms, Gene Expression Regulation, Bacterial, Mutation, Pseudomonas aeruginosa/metabolism, RNA, Bacterial/genetics, RNA, Bacterial/metabolism, Ribosomal Proteins/metabolism
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