Exenatide regulates pancreatic islet integrity and insulin sensitivity in the nonhuman primate baboon Papio hamadryas.

Détails

ID Serval
serval:BIB_893519A0D48A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Exenatide regulates pancreatic islet integrity and insulin sensitivity in the nonhuman primate baboon Papio hamadryas.
Périodique
JCI insight
Auteur(s)
Fiorentino T.V., Casiraghi F., Davalli A.M., Finzi G., La Rosa S., Higgins P.B., Abrahamian G.A., Marando A., Sessa F., Perego C., Guardado-Mendoza R., Kamath S., Ricotti A., Fiorina P., Daniele G., Paez A.M., Andreozzi F., Bastarracea R.A., Comuzzie A.G., Gastaldelli A., Chavez A.O., Di Cairano E.S., Frost P., Luzi L., Dick E.J., Halff G.A., DeFronzo R.A., Folli F.
ISSN
2379-3708 (Electronic)
ISSN-L
2379-3708
Statut éditorial
Publié
Date de publication
17/10/2019
Peer-reviewed
Oui
Volume
4
Numéro
20
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
The glucagon-like peptide-1 receptor agonist exenatide improves glycemic control by several and not completely understood mechanisms. Herein, we examined the effects of chronic intravenous exenatide infusion on insulin sensitivity, β cell and α cell function and relative volumes, and islet cell apoptosis and replication in nondiabetic nonhuman primates (baboons). At baseline, baboons received a 2-step hyperglycemic clamp followed by an l-arginine bolus (HC/A). After HC/A, baboons underwent a partial pancreatectomy (tail removal) and received a continuous exenatide (n = 12) or saline (n = 12) infusion for 13 weeks. At the end of treatment, HC/A was repeated, and the remnant pancreas (head-body) was harvested. Insulin sensitivity increased dramatically after exenatide treatment and was accompanied by a decrease in insulin and C-peptide secretion, while the insulin secretion/insulin resistance (disposition) index increased by about 2-fold. β, α, and δ cell relative volumes in exenatide-treated baboons were significantly increased compared with saline-treated controls, primarily as the result of increased islet cell replication. Features of cellular stress and secretory dysfunction were present in islets of saline-treated baboons and absent in islets of exenatide-treated baboons. In conclusion, chronic administration of exenatide exerts proliferative and cytoprotective effects on β, α, and δ cells and produces a robust increase in insulin sensitivity in nonhuman primates.
Mots-clé
B cells, Endocrinology, Glucose metabolism, Insulin signaling
Pubmed
Web of science
Création de la notice
11/11/2019 9:53
Dernière modification de la notice
30/11/2019 6:26
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