A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III.

Détails

ID Serval
serval:BIB_892E5961459A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III.
Périodique
Nature
Auteur(s)
Henry R.W., Sadowski C.L., Kobayashi R., Hernandez N.
ISSN
0028-0836
Statut éditorial
Publié
Date de publication
04/1995
Peer-reviewed
Oui
Volume
374
Numéro
6523
Pages
653-656
Langue
anglais
Résumé
The TATA-box-binding protein TBP exists in the cell complexed with different sets of TBP-associated factors (TAFs). In general, each of these TBP-TAF complexes is dedicated to transcription by a single RNA polymerase. Thus, SL1, TFIID and TFIIIB are required for transcription by polymerases I, II and III, respectively. Here we characterize a fourth TBP-TAF complex called SNAPc. Unlike the other TBP-TAF complexes, SNAPc is implicated in transcription by two types of polymerases; it is required for transcription of both the RNA polymerase II and III small-nuclear RNA genes and binds specifically to the proximal sequence element PSE, a non-TATA-box basal promoter element common to these two types of genes. In addition to TBP, SNAPc is composed of at least three TAFs, SNAP43, SNAP45 and SNAP50. The predicted amino-acid sequence of SNAP43 reveals that it corresponds to a new protein.
Mots-clé
Amino Acid Sequence, Bacteriophage lambda, Base Sequence, Cross Reactions, DNA, DNA-Binding Proteins, Hela Cells, Humans, Molecular Sequence Data, RNA Polymerase I, RNA Polymerase II, RNA, Small Nuclear, Recombinant Proteins, TATA Box, TATA-Box Binding Protein, Transcription Factors, Transcription, Genetic
Pubmed
Web of science
Création de la notice
21/01/2008 17:34
Dernière modification de la notice
20/08/2019 15:48
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