Congenital Nystagmus Gene FRMD7 Is Necessary for Establishing a Neuronal Circuit Asymmetry for Direction Selectivity.

Détails

Ressource 1Télécharger: BIB_891621F3D894.P001.pdf (6354.10 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_891621F3D894
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Congenital Nystagmus Gene FRMD7 Is Necessary for Establishing a Neuronal Circuit Asymmetry for Direction Selectivity.
Périodique
Neuron
Auteur(s)
Yonehara K., Fiscella M., Drinnenberg A., Esposti F., Trenholm S., Krol J., Franke F., Scherf B.G., Kusnyerik A., Müller J., Szabo A., Jüttner J., Cordoba F., Reddy A.P., Németh J., Nagy Z.Z., Munier F., Hierlemann A., Roska B.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Statut éditorial
Publié
Date de publication
01/2016
Peer-reviewed
Oui
Volume
89
Numéro
1
Pages
177-193
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Neuronal circuit asymmetries are important components of brain circuits, but the molecular pathways leading to their establishment remain unknown. Here we found that the mutation of FRMD7, a gene that is defective in human congenital nystagmus, leads to the selective loss of the horizontal optokinetic reflex in mice, as it does in humans. This is accompanied by the selective loss of horizontal direction selectivity in retinal ganglion cells and the transition from asymmetric to symmetric inhibitory input to horizontal direction-selective ganglion cells. In wild-type retinas, we found FRMD7 specifically expressed in starburst amacrine cells, the interneuron type that provides asymmetric inhibition to direction-selective retinal ganglion cells. This work identifies FRMD7 as a key regulator in establishing a neuronal circuit asymmetry, and it suggests the involvement of a specific inhibitory neuron type in the pathophysiology of a neurological disease. VIDEO ABSTRACT.
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/01/2016 8:37
Dernière modification de la notice
20/08/2019 14:48
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