Human chorionic gonadotropin in pregnancy and maternal risk of breast cancer.

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Serval ID
serval:BIB_890EB343C5BB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Human chorionic gonadotropin in pregnancy and maternal risk of breast cancer.
Journal
Cancer Research
Author(s)
Toniolo Paolo, Grankvist Kjell, Wulff Marianne, Chen Tianhui, Johansson Robert, Schock Helena, Lenner Per, Hallmans Göran, Lehtinen Matti, Kaaks Rudolf, Wadell Göran, Zeleniuch-Jacquotte Anne, Lundin Eva, Lukanova Annekatrin
ISSN
1538-7445[electronic], 0008-5472[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
70
Number
17
Pages
6779-6786
Language
english
Abstract
Full-term pregnancies are associated with long-term reductions in maternal risk of breast cancer, but the biological determinants of the protection are unknown. Experimental observations suggest that human chorionic gonadotropin (hCG), a major hormone of pregnancy, could play a role in this association. A case-control study (242 cases and 450 controls) nested within the Northern Sweden Maternity Cohort included women who had donated a blood sample during the first trimester of a first full-term pregnancy. Total hCG was determined on Immulite 2000 analyzer. Odds ratios (OR) and 95% confidence intervals (CI) were estimated through conditional logistic regression. Maternal breast cancer risk decreased with increasing hCG (upper tertile OR, 0.67; CI, 0.46-0.99), especially for pregnancies before age 25 (upper tertile OR, 0.41; CI, 0.21-0.80). The association diverged according to age at diagnosis: risk was reduced after age 40 (upper tertile OR, 0.60; CI, 0.39-0.91) and seemed to increase before age 40 (upper tertile OR, 1.78; CI, 0.72-4.38). Risk was reduced among those diagnosed 10 years or longer after blood draw (upper tertile OR, 0.60; CI, 0.40-0.90), but not so among those diagnosed within 10 years (upper tertile OR, 4.33; CI, 0.86-21.7). These observations suggest that the association between pregnancy hCG and subsequent maternal risk of breast cancer is modified by age at diagnosis. Although the hormone seems to be a determinant of the reduced risk around or after age 50, it might not confer protection against, or it could even increase the risk of, cancers diagnosed in the years immediately following pregnancy.
Keywords
Adolescent, Adult, Age Factors, Breast Neoplasms/blood, Breast Neoplasms/prevention & control, Case-Control Studies, Chorionic Gonadotropin/blood, Cohort Studies, Female, Humans, Middle Aged, Pregnancy, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
23/12/2010 17:21
Last modification date
20/08/2019 14:48
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