Feasibility and Safety of Pressurized Intraperitoneal Aerosol Chemotherapy for Peritoneal Carcinomatosis: A Retrospective Cohort Study.

Détails

Ressource 1Télécharger: 6852749.pdf (2174.32 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_8898F0CB1706
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Feasibility and Safety of Pressurized Intraperitoneal Aerosol Chemotherapy for Peritoneal Carcinomatosis: A Retrospective Cohort Study.
Périodique
Gastroenterology research and practice
Auteur(s)
Hübner M., Teixeira Farinha H., Grass F., Wolfer A., Mathevet P., Hahnloser D., Demartines N.
ISSN
1687-6121 (Print)
ISSN-L
1687-6121
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
2017
Pages
6852749
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Background. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) has been introduced as a novel repeatable treatment for peritoneal carcinomatosis. The available evidence from the pioneer center suggests good tolerance and high response rates, but independent confirmation is needed. A single-center cohort was analyzed one year after implementation for feasibility and safety. Methods. PIPAC was started in January 2015, and every patient was entered into a prospective database. This retrospective analysis included all consecutive patients operated until April 2016 with emphasis on surgical feasibility and early postoperative outcomes. Results. Forty-two patients (M : F = 8 : 34, median age 66 (59-73) years) with 91 PIPAC procedures in total (4×: 1,  3×: 17,  2×: 12, and  1×: 12) were analyzed. Abdominal accessibility rate was 95% (42/44); laparoscopic access was not feasible in 2 patients with previous HIPEC. Median initial peritoneal carcinomatosis index (PCI) was 10 (IQR 5-17). Median operation time was 94 min (89-108) with no learning curve observed. One PIPAC application was postponed due to intraoperative intestinal lesion. Overall morbidity was 9% with 7 minor complications (Clavien I-II) and one PIPAC-unrelated postoperative mortality. Median postoperative hospital stay was 3 days (2-3). Conclusion. Repetitive PIPAC is feasible in most patients with refractory carcinomatosis of various origins. Intraoperative complications and postoperative morbidity rates were low. This encourages prospective studies assessing oncological efficacy.

Pubmed
Web of science
Open Access
Oui
Création de la notice
04/04/2017 18:33
Dernière modification de la notice
20/08/2019 14:47
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