Changing responsiveness to chemokines allows medullary plasmablasts to leave lymph nodes.

Détails

ID Serval
serval:BIB_87F6B99531F8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Changing responsiveness to chemokines allows medullary plasmablasts to leave lymph nodes.
Périodique
European Journal of Immunology
Auteur(s)
Wehrli N., Legler D.F., Finke D., Toellner K.M., Loetscher P., Baggiolini M., MacLennan I.C., Acha-Orbea H.
ISSN
0014-2980 (Print)
ISSN-L
0014-2980
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
31
Numéro
2
Pages
609-616
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
During T cell-dependent antibody responses lymph node B cells differentiate either to plasmablasts that grow in the medullary cords, or to blasts that proliferate in follicles forming germinal centers. Many plasmablasts differentiate to plasma cells locally, but some leave the medullary cords and migrate to downstream lymph nodes. To assess the basis for this migration, changes in the responsiveness of B cells to a range of chemokines have been studied as they differentiate. Naive B cells express high levels of CCR6, CCR7, CXCR4 and CXCR5. When activated B cells grow in follicles the expression of these chemokine receptors and the responsiveness to the respective chemokines is retained. During the extrafollicular response, plasmablast expression of CXCR5 and responsiveness to B-lymphocyte chemoattractant (CXCR5) as well as to secondary lymphoid tissue chemokine (CCR7) and stromal cell-derived factor (SDF)-1 (CXCR4) are lost while a weak response towards the CCR6 chemokine LARC is maintained. Despite losing responsiveness to SDF-1, extrafollicular plasmablasts still express high levels of CXCR4 on the cell surface. These results suggest that the combined loss of chemokine receptor expression and of chemokine responsiveness may be a necessary prerequisite for cells to migrate to the medullary cords and subsequently enter the efferent lymph.
Mots-clé
Animals, B-Lymphocytes/physiology, Cell Differentiation, Cell Movement, Chemokines/physiology, Chickens, Female, Hematopoietic Stem Cells/physiology, Lymph Nodes/cytology, Mammary Tumor Virus, Mouse/immunology, Mice, Mice, Inbred BALB C, Plasma Cells/physiology, Receptors, Chemokine/analysis, Receptors, Chemokine/physiology, gamma-Globulins/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 15:48
Dernière modification de la notice
08/05/2019 21:31
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