Simultaneous Noninvasive Assessment of Systemic and Coronary Endothelial Function.

Détails

ID Serval
serval:BIB_87D35DABAF54
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Simultaneous Noninvasive Assessment of Systemic and Coronary Endothelial Function.
Périodique
Circulation.
Auteur(s)
Iantorno M., Hays A.G., Schär M., Krishnaswamy R., Soleimanifard S., Steinberg A., Stuber M., Gerstenblith G., Weiss R.G.
ISSN
1942-0080 (Electronic)
ISSN-L
1941-9651
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
9
Numéro
3
Pages
e003954
Langue
anglais
Résumé
BACKGROUND: Normal endothelial function is a measure of vascular health and dysfunction is a predictor of coronary events. Nitric oxide-mediated coronary artery endothelial function, as assessed by vasomotor reactivity during isometric handgrip exercise (IHE), was recently quantified noninvasively with magnetic resonance imaging (MRI). Because the internal mammary artery (IMA) is often visualized during coronary MRI, we propose the strategy of simultaneously assessing systemic and coronary endothelial function noninvasively by MRI during IHE.
METHODS AND RESULTS: Changes in cross-sectional area and blood flow in the right coronary artery and the IMA in 25 patients with coronary artery disease and 26 healthy subjects during IHE were assessed using 3T MRI. In 8 healthy subjects, a nitric oxide synthase inhibitor was infused to evaluate the role of nitric oxide in the IMA-IHE response. Interobserver IMA-IHE reproducibility was good for cross-sectional area (R=0.91) and blood flow (R=0.91). In healthy subjects, cross-sectional area and blood flow of the IMA increased during IHE, and these responses were significantly attenuated by monomethyl-l-arginine (P<0.01 versus placebo). In patients with coronary artery disease, the right coronary artery did not dilate with IHE, and dilation of the IMA was less than that of the healthy subjects (P=0.01). The blood flow responses of both the right coronary artery and IMA to IHE were also significantly reduced in patients with coronary artery disease.
CONCLUSIONS: MRI-detected IMA responses to IHE primarily reflect nitric oxide-dependent endothelial function and are reproducible and reduced in patients with coronary artery disease. Endothelial function in both coronary and systemic (IMA) arteries can now be measured noninvasively with the same imaging technique and promises novel insights into systemic and local factors affecting vascular health.
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/03/2016 18:51
Dernière modification de la notice
08/05/2019 21:30
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