Long noncoding RNAs in cardiac development and ageing.

Détails

ID Serval
serval:BIB_87CD8900F409
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Long noncoding RNAs in cardiac development and ageing.
Périodique
Nature Reviews. Cardiology
Auteur(s)
Devaux Y., Zangrando J., Schroen B., Creemers E.E., Pedrazzini T., Chang C.P., Dorn G.W., Thum T., Heymans S., Cardiolinc network
Contributeur(s)
Cardiolinc network
ISSN
1759-5010 (Electronic)
ISSN-L
1759-5002
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
12
Numéro
7
Pages
415-425
Langue
anglais
Résumé
A large part of the mammalian genome is transcribed into noncoding RNAs. Long noncoding RNAs (lncRNAs) have emerged as critical epigenetic regulators of gene expression. Distinct molecular mechanisms allow lncRNAs either to activate or to repress gene expression, thereby participating in the regulation of cellular and tissue function. LncRNAs, therefore, have important roles in healthy and diseased hearts, and might be targets for therapeutic intervention. In this Review, we summarize the current knowledge of the roles of lncRNAs in cardiac development and ageing. After describing the definition and classification of lncRNAs, we present an overview of the mechanisms by which lncRNAs regulate gene expression. We discuss the multiple roles of lncRNAs in the heart, and focus on the regulation of embryonic stem cell differentiation, cardiac cell fate and development, and cardiac ageing. We emphasize the importance of chromatin remodelling in this regulation. Finally, we discuss the therapeutic and biomarker potential of lncRNAs.
Mots-clé
Aging/genetics, Aging/physiology, Animals, Epigenesis, Genetic/physiology, Heart/growth & development, Heart/physiology, Humans, RNA, Long Noncoding/physiology
Pubmed
Web of science
Création de la notice
13/07/2015 12:16
Dernière modification de la notice
03/03/2018 19:03
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