Article: article from journal or magazin.
Toll-like receptor 3 is necessary for dsRNA adjuvant effects.
Toll-like receptors (TLR) recognize pathogen associated molecular patterns, and the binding of their specific ligands triggers a proinflammatory response that helps to fight invading microorganisms, and can be harnessed to increase vaccine efficiency. The present study demonstrates that double-stranded RNA is a promising vaccine adjuvant able to increase both proliferation and activation of antigen-specific CD8(+) T cells. Importantly, TLR3 is required for this adjuvant effect, as TLR3 deficient recipients failed to enhance proliferation of adoptively transferred TCR transgenic CD8(+) T cells in the presence of double-stranded RNA. Finally, this study also shows that, in contrast to previous reports in humans, TLR3 does not exert direct costimulatory activity on CD8(+) T cells in mice.
Adjuvants, Immunologic, Adsorption, Aluminum Hydroxide, Animals, Antibodies, Anti-Idiotypic, Body Temperature, DNA, Ethylene Glycols, Extracellular Fluid, Humans, Hydrogen-Ion Concentration, Indicators and Reagents, Isoelectric Focusing, Mice, Sheep, Thermodynamics, Toll-Like Receptor 3, Vaccines
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