The disease burden of Multiple Sclerosis from the individual and population perspective: Which symptoms matter most?

Détails

ID Serval
serval:BIB_879A4B0BCAE5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The disease burden of Multiple Sclerosis from the individual and population perspective: Which symptoms matter most?
Périodique
Multiple sclerosis and related disorders
Auteur(s)
Barin L., Salmen A., Disanto G., Babačić H., Calabrese P., Chan A., Kamm C.P., Kesselring J., Kuhle J., Gobbi C., Pot C., Puhan M.A., von Wyl V.
Collaborateur(s)
Swiss Multiple Sclerosis Registry (SMSR)
ISSN
2211-0356 (Electronic)
ISSN-L
2211-0348
Statut éditorial
Publié
Date de publication
10/2018
Peer-reviewed
Oui
Volume
25
Pages
112-121
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
MS symptoms affect many functional domains. Knowing the specific impact of symptoms on health-related quality of life (HRQoL) is vital for successful disease and symptom management in MS. We aimed at investigating how specific MS symptoms contribute to the disease burden in individuals and from a population perspective.
We included 855 Swiss Multiple Sclerosis Registry participants with a relapsing-remitting form (RRMS) or a progressive form (PMS). HRQoL was measured with the EuroQol 5-Dimension EQ-5D-index and EQ-Visual Analogue Scale (EQ-VAS) on 0-100% scales. Their associations with 20 symptoms, socio-demographic and clinical information were explored in median regression models, stratified by RRMS and PMS.
We included 611 participants with RRMS and 244 with PMS. In RRMS, gait (-6.5%) and balance problems (-5.1%) had the largest EQ-5D-index reductions, and were also important at the population level (frequencies 45% and 52%). Fatigue, depression, and spasticity (frequencies 74.1%, 31%, 38%) also contributed to the population disease burden. In PMS, spasticity, paralysis, and bowel problems had the largest impact on EQ-5D-index, both at the individual and population levels. The largest impact on EQ-VAS at population level was associated in RRMS with balance problems, depression, dizziness, and spasticity, while in PMS with weakness, pain, and paralysis.
While HRQoL at population level is most affected by balance problems, spasticity, and depression in RRMS, the biggest HRQoL losses in PMS are caused by spasticity, paralysis, weakness, and pain. Many symptoms with the largest effects in individuals substantially contribute to the population disease burden.
Mots-clé
Adult, Aged, Depression/etiology, Disability Evaluation, Fatigue/epidemiology, Fatigue/etiology, Female, Humans, Longitudinal Studies, Male, Memory Disorders/etiology, Middle Aged, Multiple Sclerosis/epidemiology, Multiple Sclerosis/physiopathology, Multiple Sclerosis/psychology, Paresthesia/epidemiology, Paresthesia/etiology, Quality of Life/psychology, Regression Analysis, Sexual Dysfunction, Physiological/etiology, Surveys and Questionnaires, Switzerland/epidemiology, Visual Analog Scale, Visual Perception/physiology, EQ5D, Patient care management, Patient reported outcomes, Quality of life, Registries, Regression analysis
Pubmed
Web of science
Création de la notice
07/08/2018 9:13
Dernière modification de la notice
15/01/2019 7:26
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