Comparison of the glomerular filtration rate in children by the new revised Schwartz formula and a new generalized formula.

Détails

ID Serval
serval:BIB_8799D5E5AC91
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Comparison of the glomerular filtration rate in children by the new revised Schwartz formula and a new generalized formula.
Périodique
Kidney International
Auteur(s)
Gao A., Cachat F., Faouzi M., Bardy D., Mosig D., Meyrat B.J., Girardin E., Chehade H.
ISSN
1523-1755 (Electronic)
ISSN-L
0085-2538
Statut éditorial
Publié
Date de publication
2013
Volume
83
Numéro
3
Pages
524-530
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish. PDF type: Technical notes
Résumé
The most widely used formula for estimating glomerular filtration rate (eGFR) in children is the Schwartz formula. It was revised in 2009 using iohexol clearances with measured GFR (mGFR) ranging between 15 and 75 ml/min × 1.73 m(2). Here we assessed the accuracy of the Schwartz formula using the inulin clearance (iGFR) method to evaluate its accuracy for children with less renal impairment comparing 551 iGFRs of 392 children with their Schwartz eGFRs. Serum creatinine was measured using the compensated Jaffe method. In order to find the best relationship between iGFR and eGFR, a linear quadratic regression model was fitted and a more accurate formula was derived. This quadratic formula was: 0.68 × (Height (cm)/serum creatinine (mg/dl))-0.0008 × (height (cm)/serum creatinine (mg/dl))(2)+0.48 × age (years)-(21.53 in males or 25.68 in females). This formula was validated using a split-half cross-validation technique and also externally validated with a new cohort of 127 children. Results show that the Schwartz formula is accurate until a height (Ht)/serum creatinine value of 251, corresponding to an iGFR of 103 ml/min × 1.73 m(2), but significantly unreliable for higher values. For an accuracy of 20 percent, the quadratic formula was significantly better than the Schwartz formula for all patients and for patients with a Ht/serum creatinine of 251 or greater. Thus, the new quadratic formula could replace the revised Schwartz formula, which is accurate for children with moderate renal failure but not for those with less renal impairment or hyperfiltration.
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/04/2013 9:35
Dernière modification de la notice
08/05/2019 21:30
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