Immune response to purified non-A, non-B hepatitis-related antigen demonstrated by leukocyte migration inhibition in patients recovering from the infection

Détails

ID Serval
serval:BIB_878F67C96F60
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Immune response to purified non-A, non-B hepatitis-related antigen demonstrated by leukocyte migration inhibition in patients recovering from the infection
Périodique
Infection
Auteur(s)
Nicole  A., Spertini  O., Lavanchy  D., Frei  P. C.
ISSN
0300-8126 (Print)
Statut éditorial
Publié
Date de publication
02/1986
Volume
14
Numéro
1
Pages
13-16
Langue
anglais
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Jan-Feb
Résumé
Eight patients, convalescent from acute hepatitis, all negative for HBsAg, anti-HBc, anti-HA-IgM, anti-CMV and anti-EB, and all positive for non-A, non-B related antigen and/or antibody in at least one sample during the course of disease, were investigated. Their specific cell-mediated immunity was tested using the leukocyte migration inhibition test in presence of a previously described non-A, non-B related antigen. A control group consisted of ten individuals (two normal subjects, six patients recovering from acute hepatitis B and two with autoimmune chronic active hepatitis). Leukocyte migration was inhibited by the antigen in seven of the eight patients. The test was negative in all control subjects. It is thus demonstrated that after recovery, patients with non-A, non-B viral hepatitis develop a cellular immune response specific for purified non-A, non-B related antigen. The association between the described antigen and viral hepatitis non-A, non-B can now be established not only by immunoprecipitation, but also by a cellular test.
Mots-clé
Adult Aged Antibodies, Viral/analysis Antigens, Viral/*immunology *Cell Migration Inhibition Female Hepatitis B Surface Antigens/analysis Hepatitis C/*immunology Hepatitis C Antigens Hepatitis, Viral, Human/*immunology Humans Leukocytes/*immunology Male Middle Aged
Pubmed
Web of science
Création de la notice
25/01/2008 16:31
Dernière modification de la notice
03/03/2018 19:02
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