Impact of Latent Tuberculosis on Diabetes.

Tepekule, B.; Kusejko, K.; Zeeb, M.; Tarr, P.E.; Calmy, A.; Battegay, M.; Furrer, H.; Cavassini, M.; Bernasconi, E.; Notter, J.; Günthard, H.F.; Nemeth, J.; Kouyos, R.D.

doi:10.1093/infdis/jiac054

Impact of Latent Tuberculosis on Diabetes.

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Serval ID

serval:BIB_878BF720EE16

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Impact of Latent Tuberculosis on Diabetes.

Journal

The Journal of infectious diseases

Author(s)

Tepekule B., Kusejko K., Zeeb M., Tarr P.E., Calmy A., Battegay M., Furrer H., Cavassini M., Bernasconi E., Notter J., Günthard H.F., Nemeth J., Kouyos R.D.

Working group(s)

Swiss HIV Cohort Study

Contributor(s)

Abela I., Aebi-Popp K., Anagnostopoulos A., Battegay M., Bernasconi E., Braun D.L., Bucher H.C., Calmy A., Cavassini M., Ciuffi A., Dollenmaier G., Egger M., Elzi L., Fehr J., Fellay J., Furrer H., Fux C.A., Günthard H.F., Hachfeld A., Haerry D., Hasse B., Hirsch H.H., Hoffmann M., Hösli I., Huber M., Kahlert C.R., Kaiser L., Keiser O., Klimkait T., Kouyos R.D., Kovari H., Kusejko K., Martinetti G., Martinez de Tejada B., Marzolini C., Metzner K.J., Müller N., Nemeth J., Nicca D., Paioni P., Pantaleo G., Perreau M., Rauch A., Schmid P., Speck R., Stöckle M., Tarr P., Trkola A., Wandeler G., Yerly S.

ISSN

1537-6613 (Electronic)

ISSN-L

0022-1899

Publication state

Published

Issued date

15/06/2022

Peer-reviewed

Oui

Volume

225

Number

Pages

2229-2234

Language

english

Notes

Publication types: Journal Article
Publication Status: ppublish

Abstract

While an increased risk of active and latent tuberculosis infection (LTBI) in people with type-2 diabetes (DM) has been demonstrated, it is less well characterized whether LTBI is associated with an increased risk of developing DM. We investigated the link between LTBI and DM in people living with HIV in the Swiss HIV Cohort Study via time-dependent Cox proportional hazards models. We found that LTBI significantly increased the risk of developing DM (HR = 1.47), which was robust across different adjustment and censoring techniques. Our results thus suggest that LTBI may be associated with an increased risk of developing DM.

Keywords

Cohort Studies, Diabetes Mellitus, Type 2/complications, HIV Infections/complications, Humans, Latent Tuberculosis/complications, Latent Tuberculosis/epidemiology, heterologous immunity, inflammatory diseases, innate immunity, latent tuberculosis, low-grade inflammation, type-2 diabetes mellitus

OAI-PMH

oai:serval.unil.ch:BIB_878BF720EE16

DOI

10.1093/infdis/jiac054

Pubmed

35172332

Web of science

000763532900001

Open Access

Yes

Create date

19/02/2022 11:12