Radioimmunoassay for 3,3',5'-triiodo-L-thyronine in unextracted serum: method and clinical results

Détails

ID Serval
serval:BIB_878A1DC904F0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Radioimmunoassay for 3,3',5'-triiodo-L-thyronine in unextracted serum: method and clinical results
Périodique
Journal of Clinical Endocrinology and Metabolism
Auteur(s)
Nicod  P., Burger  A., Staeheli  V., Vallotton  M. B.
ISSN
0021-972X (Print)
Statut éditorial
Publié
Date de publication
05/1976
Volume
42
Numéro
5
Pages
823-9
Notes
Journal Article --- Old month value: May
Résumé
Serum 3,3',5'-triiodothyronine (rT3) was measured with a radioimmunoassay in unextracted serum. The assay was specific and reproducible. The coefficients of variation for 3 different sera known for high, normal, and low rT3 concentrations between assays were 4, 6, and 9% within assays 4, 9, and 7%, respectively. In euthyroid subjects 20 to 60 years old, rT3 was 450 +/- 200 pg/ml (mean +/- 2 SD.n = 83). Serum rT3 was found to be increased in hyperthyroidism (range: 762-2581 pg-ml; n = 11) but also in acute and chronic illness (up to 2400 pg/ml; n = 24) and in anorexia nervosa (536-1058 pg/ml; n = 7). In the latter two situations there was mostly an inverse change in serum 3,5,3'-triiodothyronine (T3) which was in the low normal range or decreased. These findings suggest a metabolic control of thyroxine deiodination. A low serum rT3 was found in 9 of 12 hypothyroid patients and in the serum of 1 chronically ill patient. Long-term treatment (1-7 years) with lithium carbonate slightly reduced serum rT3, although the changes were inside the normal range. Kidney function was not found to be necessary for its production as anephric patients had normal rT3 values. In addition, hemodialysis increased serum rT3, which is probably due to the heparin therapy.
Mots-clé
Adolescent Adult Aged Anorexia Nervosa/blood Child Female Humans Hyperthyroidism/blood Hypothyroidism/blood Infant, Newborn Kidney Failure, Chronic/blood Lithium/therapeutic use Male Middle Aged Pregnancy Radioimmunoassay/*methods Renal Dialysis Thyroxine/metabolism Triiodothyronine/*blood
Pubmed
Web of science
Création de la notice
25/01/2008 15:00
Dernière modification de la notice
03/03/2018 19:02
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