Different effector mechanisms for ATP and adenosine hyperpolarization in the guinea-pig taenia coli

Détails

ID Serval
serval:BIB_8784E093E756
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Different effector mechanisms for ATP and adenosine hyperpolarization in the guinea-pig taenia coli
Périodique
European Journal of Pharmacology
Auteur(s)
Ferrero  J. D., Frischknecht  R.
ISSN
0014-2999 (Print)
Statut éditorial
Publié
Date de publication
01/1983
Peer-reviewed
Oui
Volume
87
Numéro
1
Pages
151-4
Notes
Comparative Study In Vitro Journal Article Research Support, Non-U.S. Gov't --- Old month value: Jan 28
Résumé
The hyperpolarizations in response to ATP and adenosine in the guinea-pig taenia coli, measured by the sucrose-gap technique at room temperature, were compared in solutions of modified ionic composition. ATP hyperpolarization was increased in low chloride and in low potassium, but was reduced to 12% of control in calcium-free solution on second application of the agonist. The response to adenosine, however, was decreased in low chloride, unchanged in low potassium and was 45% of control in calcium-free solution. The different mechanisms for ATP and adenosine hyperpolarization provide evidence for the presence of separate receptors.
Mots-clé
Adenosine/*pharmacology Adenosine Triphosphate/*pharmacology Animals Calcium/pharmacology Chlorides/pharmacology Colon/drug effects Female Guinea Pigs Male Membrane Potentials/drug effects Muscle, Smooth/*drug effects Potassium/pharmacology Receptors, Cell Surface/metabolism Receptors, Purinergic
Pubmed
Web of science
Création de la notice
25/01/2008 9:34
Dernière modification de la notice
03/03/2018 19:02
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