Article: article from journal or magazin.
Different effector mechanisms for ATP and adenosine hyperpolarization in the guinea-pig taenia coli
European Journal of Pharmacology
Comparative Study In Vitro Journal Article Research Support, Non-U.S. Gov't --- Old month value: Jan 28
The hyperpolarizations in response to ATP and adenosine in the guinea-pig taenia coli, measured by the sucrose-gap technique at room temperature, were compared in solutions of modified ionic composition. ATP hyperpolarization was increased in low chloride and in low potassium, but was reduced to 12% of control in calcium-free solution on second application of the agonist. The response to adenosine, however, was decreased in low chloride, unchanged in low potassium and was 45% of control in calcium-free solution. The different mechanisms for ATP and adenosine hyperpolarization provide evidence for the presence of separate receptors.
Adenosine/*pharmacology Adenosine Triphosphate/*pharmacology Animals Calcium/pharmacology Chlorides/pharmacology Colon/drug effects Female Guinea Pigs Male Membrane Potentials/drug effects Muscle, Smooth/*drug effects Potassium/pharmacology Receptors, Cell Surface/metabolism Receptors, Purinergic
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