Ecological temporal stability of Staphylococcus aureus nasal carriage.

Détails

ID Serval
serval:BIB_87816D8E6F69
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Ecological temporal stability of Staphylococcus aureus nasal carriage.
Périodique
Journal of Clinical Microbiology
Auteur(s)
Sakwinska O., Blanc D.S., Lazor-Blanchet C., Moreillon M., Giddey M., Moreillon P.
ISSN
1098-660X (Electronic)
ISSN-L
0095-1137
Statut éditorial
Publié
Date de publication
2010
Volume
48
Numéro
8
Pages
2724-2728
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
We described the colonization dynamics of Staphylococcus aureus in a group of 266 healthy carriers over a period of approximately 1 year. We used precise genotyping methods, i.e., amplified fragment length polymorphism (AFLP), spa typing, and double-locus sequence typing (DLST), to detect changes in strain identity. Strain change took place rather rarely: out of 89 carriers who had initially been colonized, only 7 acquired a strain different from the original one. Approximately one-third of the carriers eliminated the colonization, and a similar number became newly colonized. Some of these events probably represent detection failure rather than genuine colonization loss or acquisition. Lower bacterial counts were associated with increased probability of eliminating the colonization. We have confirmed a high mutation rate in the spa locus: 6 out of 53 strains underwent mutation in the spa locus. There was no overall change in S. aureus genotype composition.
Mots-clé
Adult, Bacterial Typing Techniques, Biodiversity, Carrier State/microbiology, Colony Count, Microbial, DNA Fingerprinting, DNA, Bacterial/genetics, Genotype, Humans, Male, Mutation, Nasal Mucosa/microbiology, Polymorphism, Genetic, Sequence Analysis, DNA, Staphylococcal Infections/microbiology, Staphylococcal Protein A/genetics, Staphylococcus aureus/isolation & purification
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/01/2011 15:34
Dernière modification de la notice
10/05/2019 10:52
Données d'usage