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BAFF AND APRIL: a tutorial on B cell survival.
Annual Review of Immunology
BAFF, a member of the TNF family, is a fundamental survival factor for transitional and mature B cells. BAFF overexpression leads to an expanded B cell compartment and autoimmunity in mice, and elevated amounts of BAFF can be found in the serum of autoimmune patients. APRIL is a related factor that shares receptors with BAFF yet appears to play a different biological role. The BAFF system provides not only potential insight into the development of autoreactive B cells but a relatively simple paradigm to begin considering the balancing act between survival, growth, and death that affects all cells.
Animals, Autoimmunity, B-Cell Activating Factor, B-Cell Activation Factor Receptor, B-Lymphocytes/cytology, B-Lymphocytes/immunology, Cell Survival, Disease Models, Animal, Humans, Immune Tolerance, Immunoglobulin A/metabolism, Ligands, Membrane Proteins/chemistry, Membrane Proteins/genetics, Mice, Mice, Transgenic, Receptors, Tumor Necrosis Factor/chemistry, Receptors, Tumor Necrosis Factor/genetics, Signal Transduction, Tumor Necrosis Factor Ligand Superfamily Member 13, Tumor Necrosis Factor-alpha/chemistry, Tumor Necrosis Factor-alpha/genetics
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