A novel pathway of antigen presentation by dendritic and endothelial cells: Implications for allorecognition and infectious diseases

Détails

ID Serval
serval:BIB_8778B19E830A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
A novel pathway of antigen presentation by dendritic and endothelial cells: Implications for allorecognition and infectious diseases
Périodique
Transplantation
Auteur(s)
Smyth  L. A., Herrera  O. B., Golshayan  D., Lombardi  G., Lechler  R. I.
ISSN
0041-1337 (Print)
Statut éditorial
Publié
Date de publication
07/2006
Volume
82
Numéro
1 Suppl
Pages
S15-8
Notes
Journal Article
Review --- Old month value: Jul 15
Résumé
Dendritic cells (DCs) are the major antigen presenting cells capable of stimulating T cell responses following either organ transplantation or a viral infection. In the context of allorecognition, T cells can be activated following presentation of alloantigens by donor DCs (direct), as well as by recipient DCs presenting processed donor major histocompatibility complex (MHC) as peptides (indirect). We have recently described another mechanism by which alloreactive T cells are activated. Recipient DCs can acquire donor MHC through cell-to-cell contact and this acquired MHC can stimulate a T cell response (the semidirect pathway). Similarly, during a viral infection, DCs are capable of stimulating T cells directly, as occurs when infected DCs present processed viral antigens, or indirectly by a process known as cross-presentation. Although cross-presentation of exogenous antigen is an important mechanism for controlling infectious diseases, it is possible that peptide:MHC acquisition (the semidirect pathway) may also play a part in immunity against pathogens. In this review, we discuss the possible contributions of the semidirect pathway/MHC transfer in infectious disease.
Mots-clé
*Antigen Presentation Communicable Diseases/*immunology Cross-Priming/*immunology Dendritic Cells/*immunology Endothelial Cells/*immunology Humans Isoantigens/immunology Lymphocyte Activation Major Histocompatibility Complex/immunology T-Lymphocytes/immunology
Pubmed
Web of science
Création de la notice
25/01/2008 14:45
Dernière modification de la notice
03/03/2018 19:02
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