How to master the host immune system? Leishmania parasites have the solutions!

Détails

Ressource 1Télécharger: dxx075.pdf (693.41 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_8774637093C2
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
How to master the host immune system? Leishmania parasites have the solutions!
Périodique
International immunology
Auteur(s)
Rossi M., Fasel N.
ISSN
1460-2377 (Electronic)
ISSN-L
0953-8178
Statut éditorial
Publié
Date de publication
10/03/2018
Peer-reviewed
Oui
Volume
30
Numéro
3
Pages
103-111
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Infection by protozoan parasites of the genus Leishmania results in the development of leishmaniasis, an increasingly prevalent group of diseases affecting over 12 million people worldwide. Leishmaniasis can have very different outcomes ranging from cutaneous lesions, mucosal lesions to visceralization depending on the species of the infecting parasite and on the immune response developed by the host. As an obligate intracellular parasite, residing within macrophages, Leishmania evolved in strict contact with the host immune system, developing different mechanisms to evade or modulate the immune response. Various types of immune responses are observed during different Leishmania spp. infections, resulting in parasite clearance but also contributing to the pathogenesis, thus increasing the complexity of the course of the disease. Interestingly, depending on the type of leishmaniasis developed, opposite treatment strategies, which either boost or inhibit the inflammatory response, have shown efficacy. In this review, we summarize the contribution of different immune cell types to the development of the anti-leishmanial immune response and the parasite strategies to evade and modulate host immunity. Further, we discuss the involvement of co-infecting pathogens in the determination of the outcome of leishmaniasis and on the effectiveness of treatment and the implication of the immune response for treatment and vaccine development.
Mots-clé
Animals, Humans, Leishmania/immunology, Leishmaniasis/immunology, Leishmaniasis/parasitology, Leishmaniasis Vaccines/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
12/01/2018 9:09
Dernière modification de la notice
08/05/2019 21:29
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