Zinc status affects neurotransmitter activity in the paraventricular nucleus of rats

Détails

ID Serval
serval:BIB_875C594C409C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Zinc status affects neurotransmitter activity in the paraventricular nucleus of rats
Périodique
Journal of Nutrition
Auteur(s)
Huntington  C. E., Shay  N. F., Grouzmann  E., Arseneau  L. M., Beverly  J. L.
ISSN
0022-3166 (Print)
Statut éditorial
Publié
Date de publication
02/2002
Volume
132
Numéro
2
Pages
270-5
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Feb
Résumé
Alterations in neurochemical activity in the paraventricular nucleus (PVN) of the hypothalamus may account for decreased intake of zinc-deficient diets. Male Sprague-Dawley rats were fed zinc-deficient (ZD) or zinc-adequate (ZA) diet for 14 d before samples of extracellular fluid in the PVN were collected by microdialysis or push-pull perfusion. A third set of rats was pair-fed (PF) an amount of ZA diet equal to the intake of ZD rats. Samples were collected over a 2-h period spanning the transition from light to dark. All rats then consumed the zinc adequate diet ad libitum for 3 d before a second set of samples was collected. The increase in extracellular norepineprhrine (NE) during h 1 of the dark period to 147 +/- 13% of baseline (P < 0.05) was apparent only in ZA rats at d 14. After the 3-d repletion period, the increase in NE at dark onset occurred in all three groups. An increase in extracellular neuropeptide Y (NPY) at dark onset to 174 +/- 32% of baseline in rats fed ZA (P < 0.01) was measured in all three groups at both d 14 and 17. Basal NPY concentrations were significantly elevated in PF rats on d 14 (7.45 +/- 2.01 vs. 0.58 +/- 0.23 pmol/L, P = 0.01) and returned to ZA levels by d 17. The activities of the NE and NPY systems in the PVN were altered in rats fed a zinc-deficient diet; however, it is unclear whether the disruption in the NE and NPY neural systems in the PVN results in the altered feeding behavior accompanying zinc deficiency.
Mots-clé
Animals Darkness Feeding Behavior/drug effects Male Microdialysis Neuropeptide Y/*metabolism Norepinephrine/*metabolism Paraventricular Hypothalamic Nucleus/*metabolism/physiology Perfusion Rats Rats, Sprague-Dawley Time Factors Zinc/*administration & dosage/*deficiency
Pubmed
Web of science
Création de la notice
25/01/2008 11:55
Dernière modification de la notice
03/03/2018 19:01
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