Lessons from mouse mutants of epithelial sodium channel and its regulatory proteins

Details

Serval ID
serval:BIB_875A61CCE224
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Lessons from mouse mutants of epithelial sodium channel and its regulatory proteins
Journal
Journal of the American Society of Nephrology
Author(s)
Hummler E., Vallon V.
ISSN
1046-6673 (Print)
Publication state
Published
Issued date
11/2005
Volume
16
Number
11
Pages
3160-66
Notes
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review --- Old month value: Nov
Abstract
The use of gene-modified mouse models allows the experimental in vivo analysis of specific gene defects at the level of target cells. With respect to the epithelial sodium channel and some of its regulatory proteins, gene-modified models that control gene defects in a time- and tissue-dependent conditional or constitutive manner have been generated. The combination of molecular and physiologic approaches in these mouse models increases the understanding of the complex regulation and the cell signaling cascades involved in Na(+) transport in target cells and may ultimately provide new insights into the pathophysiology of renal Na(+) retention and BP regulation. This review summarizes and discusses the gene-targeting approaches that have been applied to the epithelial sodium channel and its regulatory proteins.
Keywords
Animals Epithelial Sodium Channel Gene Expression Regulation Mice Mice, Knockout Models, Animal Mutagenesis Protein Isoforms/genetics Receptors, Mineralocorticoid/genetics Sodium Channels/deficiency/*genetics
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 12:43
Last modification date
20/08/2019 14:46
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