Lessons from mouse mutants of epithelial sodium channel and its regulatory proteins

Détails

ID Serval
serval:BIB_875A61CCE224
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Lessons from mouse mutants of epithelial sodium channel and its regulatory proteins
Périodique
Journal of the American Society of Nephrology
Auteur(s)
Hummler E., Vallon V.
ISSN
1046-6673 (Print)
Statut éditorial
Publié
Date de publication
11/2005
Volume
16
Numéro
11
Pages
3160-66
Notes
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review --- Old month value: Nov
Résumé
The use of gene-modified mouse models allows the experimental in vivo analysis of specific gene defects at the level of target cells. With respect to the epithelial sodium channel and some of its regulatory proteins, gene-modified models that control gene defects in a time- and tissue-dependent conditional or constitutive manner have been generated. The combination of molecular and physiologic approaches in these mouse models increases the understanding of the complex regulation and the cell signaling cascades involved in Na(+) transport in target cells and may ultimately provide new insights into the pathophysiology of renal Na(+) retention and BP regulation. This review summarizes and discusses the gene-targeting approaches that have been applied to the epithelial sodium channel and its regulatory proteins.
Mots-clé
Animals Epithelial Sodium Channel Gene Expression Regulation Mice Mice, Knockout Models, Animal Mutagenesis Protein Isoforms/genetics Receptors, Mineralocorticoid/genetics Sodium Channels/deficiency/*genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 13:43
Dernière modification de la notice
08/05/2019 21:29
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