Methodology of H NMR Spectroscopy of the Human Brain at Very High Magnetic Fields.

Détails

ID Serval
serval:BIB_8731B84C8BA0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Methodology of H NMR Spectroscopy of the Human Brain at Very High Magnetic Fields.
Périodique
Applied Magnetic Resonance
Auteur(s)
Tkáč I., Gruetter R.
ISSN
0937-9347 (Print)
ISSN-L
0937-9347
Statut éditorial
Publié
Date de publication
2005
Volume
29
Numéro
1
Pages
139-157
Langue
anglais
Notes
Publication types: JOURNAL ARTICLEPublication Status: ppublish
Résumé
An ultrashort-echo-time stimulated echo-acquisition mode (STEAM) pulse sequence with interleaved outer volume suppression and VAPOR (variable power and optimized relaxation delays) water suppression was redesigned and optimized for human applications at 4 and 7 T, taking into account the specific requirements for spectroscopy at high magnetic fields and limitations of currently available hardware. In combination with automatic shimming, automated parameter adjustments and data processing, this method provided a user-friendly tool for routine (1)H nuclear magnetic resonance (NMR) spectroscopy of the human brain at very high magnetic fields. Effects of first- and second-order shimming, single-scan averaging, frequency and phase corrections, and eddy currents were described. LCModel analysis of an in vivo (1)H NMR spectrum measured from the human brain at 7 T allowed reliable quantification of more than fifteen metabolites noninvasively, illustrating the potential of high-field NMR spectroscopy. Examples of spectroscopic studies performed at 4 and 7 T demonstrated the high reproducibility of acquired spectra quality.
Pubmed
Web of science
Création de la notice
04/08/2010 16:28
Dernière modification de la notice
03/03/2018 19:01
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