The effect of six different statins on the proliferation, migration, and invasion of human smooth muscle cells.

Détails

ID Serval
serval:BIB_87227FAA1A5E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The effect of six different statins on the proliferation, migration, and invasion of human smooth muscle cells.
Périodique
Journal of Surgical Research
Auteur(s)
Corpataux J.M., Naik J., Porter K.E., London N.J.
ISSN
0022-4804
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
129
Numéro
1
Pages
52-56
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article
Résumé
Intimal hyperplasia (IH) can occur after any vascular injury and results from smooth muscle cells (SMC) proliferation, migration, and invasion into the subintimal space. The purpose of this study was to investigate the effect of six different statins on the proliferation, migration, and invasion of human venous SMC. The statins were all used at their Cmax concentrations. SMCs were used to construct growth curves in the presence of 10% fetal calf serum or 10% fetal calf serum supplemented with the six statins. Migration and invasion experiments were performed using modified Boyden chambers. The invasion experiments were performed using Matrigel coated plates. We found that all of the statins significantly inhibited SMC proliferation compared to the platelet-derived growth factor control (ranging from fluvastatin 33% of control to pravastatin 72% of control, P = 0.03). SMC migration through uncoated polycarbonate membranes in presence of the six statins was significantly reduced (ranging from lovastatin 43% to pravastatin 57% of control, P = 0.006). All six statins also significantly reduced SMC invasion (ranging from fluvastatin 65% to simvastatin 87% of control, P = 0.002). We conclude that the inhibitory effect of statins on SMC proliferation, migration, and invasion is a class, rather than drug specific effect.
Mots-clé
Cell Division, Cell Movement, Chemotaxis, Fatty Acids, Monounsaturated, Heptanoic Acids, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Indoles, Lovastatin, Myocytes, Smooth Muscle, Pravastatin, Pyridines, Pyrroles, Saphenous Vein, Simvastatin
Pubmed
Web of science
Création de la notice
28/01/2008 10:01
Dernière modification de la notice
03/03/2018 19:01
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