Immunotherapy in gastrointestinal cancer: Recent results, current studies and future perspectives.

Détails

ID Serval
serval:BIB_8719495746AA
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Immunotherapy in gastrointestinal cancer: Recent results, current studies and future perspectives.
Périodique
European Journal of Cancer
Auteur(s)
Moehler M., Delic M., Goepfert K., Aust D., Grabsch H.I., Halama N., Heinrich B., Julie C., Lordick F., Lutz M.P., Mauer M., Alsina Maqueda M., Schild H., Schimanski C.C., Wagner A.D., Roth A., Ducreux M.
ISSN
1879-0852 (Electronic)
ISSN-L
0959-8049
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
59
Pages
160-170
Langue
anglais
Résumé
The new therapeutic approach of using immune checkpoint inhibitors as anticancer agents is a landmark innovation. Early studies suggest that immune checkpoint inhibition might also be effective in patients with gastrointestinal cancer. To improve the efficacy of immunotherapy, different strategies are currently under evaluation. This review summarises the discussion during the European Organisation for Research and Treatment of Cancer Gastrointestinal Tract Cancer Translational Research Meeting in Mainz in November 2014 and provides an update on the most recent results of immune therapy in gastrointestinal cancers. Knowledge of potential relationships between tumour cells and their microenvironment including the immune system will be essential in gastrointestinal malignancies. In this context, the density of T cell infiltration within colorectal cancer metastases has been associated with response to chemotherapy, and a high expression of programmed cell death ligand 1 (PD-L1) in advanced gastric cancer has been related with poor prognosis. Effective targets might include neo-antigens encoded from genes carrying tumour-specific somatic mutations. Tailored immunotherapy based on such mutations could enable the effective targeting of an individual patient's tumour with vaccines produced on demand. Other strategies considering checkpoint inhibitors have shown efficacy by targeting cytotoxic T-lymphocyte-associated protein 4 and PD-1 or PD-L1. DNA mismatch repair-deficient tumours appear to be potentially the best candidates for these therapies. Finally, the combination of oncolytic viruses with immunotherapy might boost antitumour activity as well. Further evaluation of these promising immunological therapeutic approaches will require large prospective clinical studies.
Pubmed
Web of science
Création de la notice
14/04/2016 17:37
Dernière modification de la notice
03/03/2018 19:01
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