Plasticity of lifespan: a reaction norm perspective.

Détails

ID Serval
serval:BIB_870FB044D8C0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Plasticity of lifespan: a reaction norm perspective.
Périodique
Proceedings of the Nutrition Society
Auteur(s)
Flatt T.
ISSN
1475-2719 (Electronic)
ISSN-L
0029-6651
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
73
Numéro
4
Pages
532-542
Langue
anglais
Résumé
It is a well-appreciated fact that in many organisms the process of ageing reacts highly plastically, so that lifespan increases or decreases when the environment changes. The perhaps best-known example of such lifespan plasticity is dietary restriction (DR), a phenomenon whereby reduced food intake without malnutrition extends lifespan (typically at the expense of reduced fecundity) and which has been documented in numerous species, from invertebrates to mammals. For the evolutionary biologist, DR and other cases of lifespan plasticity are examples of a more general phenomenon called phenotypic plasticity, the ability of a single genotype to produce different phenotypes (e.g. lifespan) in response to changes in the environment (e.g. changes in diet). To analyse phenotypic plasticity, evolutionary biologists (and epidemiologists) often use a conceptual and statistical framework based on reaction norms (genotype-specific response curves) and genotype × environment interactions (G × E; differences in the plastic response among genotypes), concepts that biologists who are working on molecular aspects of ageing are usually not familiar with. Here I briefly discuss what has been learned about lifespan plasticity or, more generally, about plasticity of somatic maintenance and survival ability. In particular, I argue that adopting the conceptual framework of reaction norms and G × E interactions, as used by evolutionary biologists, is crucially important for our understanding of the mechanisms underlying DR and other forms of lifespan or survival plasticity.
Mots-clé
Lifespan, Ageing, Phenotypic plasticity, Reaction norms, Genotype x environment interactions, Dietary restriction, Nutritional geometry
Pubmed
Web of science
Open Access
Oui
Création de la notice
16/10/2014 13:56
Dernière modification de la notice
20/08/2019 15:46
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