Positive contrast MR-lymphography using inversion recovery with ON-resonant water suppression (IRON).

Détails

ID Serval
serval:BIB_8707C137D116
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Positive contrast MR-lymphography using inversion recovery with ON-resonant water suppression (IRON).
Périodique
Journal of Magnetic Resonance Imaging
Auteur(s)
Korosoglou G., Tang L., Kedziorek D., Cosby K., Gilson W.D., Vonken E.J., Schär M., Sosnovik D., Kraitchman D.L., Weiss R.G., Weissleder R., Stuber M.
ISSN
1053-1807[print], 1053-1807[linking]
Statut éditorial
Publié
Date de publication
2008
Volume
27
Numéro
5
Pages
1175-1180
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
PURPOSE: To investigate the utility of inversion recovery with ON-resonant water suppression (IRON) to create positive signal in normal lymph nodes after injection of superparamagnetic nanoparticles. MATERIALS AND METHODS: Experiments were conducted on six rabbits, which received a single bolus injection of 80 mumol Fe/kg monocrystalline iron oxide nanoparticle (MION-47). Magnetic resonance imaging (MRI) was performed at baseline, 1 day, and 3 days after MION-47 injection using conventional T(1)- and T(2)*-weighted sequences and IRON. Contrast-to-noise ratios (CNR) were measured in blood and in paraaortic lymph nodes. RESULTS: On T(2)*-weighted images, as expected, signal attenuation was observed in areas of paraaortic lymph nodes after MION-47 injection. However, using IRON the paraaortic lymph nodes exhibited very high contrast enhancement, which remained 3 days after injection. CNR with IRON was 2.2 +/- 0.8 at baseline, increased markedly 1 day after injection (23.5 +/- 5.4, P < 0.01 vs. baseline), and remained high after 3 days (21.8 +/- 5.7, *P < 0.01 vs. baseline). CNR was also high in blood 1 day after injection (42.7 +/- 7.2 vs. 1.8 +/- 0.7 at baseline, P < 0.01) but approached baseline after 3 days (1.9 +/- 1.4, P = NS vs. baseline). CONCLUSION: IRON in conjunction with superparamagnetic nanoparticles can be used to perform 'positive contrast' MR-lymphography, particularly 3 days after injection of the contrast agent, when signal is no longer visible within blood vessels. The proposed method may have potential as an adjunct for nodal staging in cancer screening.
Mots-clé
Abdomen, Analysis of Variance, Animals, Contrast Media/administration & dosage, Contrast Media/pharmacokinetics, Ferrosoferric Oxide, Image Processing, Computer-Assisted, Injections, Iron/administration & dosage, Iron/pharmacokinetics, Lymph Nodes/metabolism, Magnetic Resonance Imaging/methods, Male, Nanoparticles, Oxides/administration & dosage, Oxides/pharmacokinetics, Rabbits
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/03/2010 17:04
Dernière modification de la notice
20/08/2019 15:46
Données d'usage