Determination of amitriptyline in the hair of psychiatric patients.

Détails

ID Serval
serval:BIB_86D8BB32720F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Determination of amitriptyline in the hair of psychiatric patients.
Périodique
Human and Experimental Toxicology
Auteur(s)
Tracqui A., Kreissig P., Kintz P., Pouliquen A., Mangin P.
ISSN
0960-3271[print], 0960-3271[linking]
Statut éditorial
Publié
Date de publication
1992
Volume
11
Numéro
5
Pages
363-367
Langue
anglais
Résumé
A study was conducted on 60 psychiatric patients to evaluate the reliability of a drug-exposure screening test based on gas chromatography/mass spectrometry analysis of hair samples for amitriptyline, and the possibility of using the hair concentrations of amitriptyline to monitor patients' therapeutic compliance. The qualitative test was found to be very reliable (sensitivity 93.3%; specificity 100%; positive and negative predictive values 100 and 93.8%) in assessing the consumer status of patients over a period of 2 months before analysis. Hair levels of amitriptyline ranged from 0 to 17.21 ng mg-1. A significant relationship (r = 0.563; P < 0.002) was found between the hair concentrations and the cumulative intake of amitriptyline over the studied period, but was not judged close enough to estimate one individual's therapeutic compliance. The results are discussed in the light of existing literature.
Mots-clé
Adolescent, Adult, Aged, Amitriptyline/administration & dosage, Amitriptyline/analysis, Female, Hair/chemistry, Humans, Male, Mental Disorders/metabolism, Middle Aged
Pubmed
Création de la notice
18/10/2010 14:57
Dernière modification de la notice
03/03/2018 19:00
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