Common genetic variation and the control of HIV-1 in humans.

Détails

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_86D58F4F4348
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Common genetic variation and the control of HIV-1 in humans.
Périodique
PLoS genetics
Auteur(s)
Fellay J., Ge D., Shianna K.V., Colombo S., Ledergerber B., Cirulli E.T., Urban T.J., Zhang K., Gumbs C.E., Smith J.P., Castagna A., Cozzi-Lepri A., De Luca A., Easterbrook P., Günthard H.F., Mallal S., Mussini C., Dalmau J., Martinez-Picado J., Miro J.M., Obel N., Wolinsky S.M., Martinson J.J., Detels R., Margolick J.B., Jacobson L.P., Descombes P., Antonarakis S.E., Beckmann J.S., O'Brien S.J., Letvin N.L., McMichael A.J., Haynes B.F., Carrington M., Feng S., Telenti A., Goldstein D.B.
Collaborateur(s)
NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)
ISSN
1553-7404 (Electronic)
ISSN-L
1553-7390
Statut éditorial
Publié
Date de publication
12/2009
Peer-reviewed
Oui
Volume
5
Numéro
12
Pages
e1000791
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
Publication Status: ppublish
Résumé
To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.

Mots-clé
Adult, Alleles, Disease Progression, Female, Genetic Variation, Genotype, HIV Infections/virology, HIV-1/physiology, Humans, Kaplan-Meier Estimate, Major Histocompatibility Complex/genetics, Male, Phenotype, Polymorphism, Single Nucleotide/genetics, Viral Load
Pubmed
Web of science
Création de la notice
26/01/2010 15:28
Dernière modification de la notice
03/03/2018 19:00
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