Combined use of 18F-fluorodeoxyglucose and 11C-methionine in 45 positron emission tomography-guided stereotactic brain biopsies.

Détails

ID Serval
serval:BIB_86BA6CCD5ED5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Combined use of 18F-fluorodeoxyglucose and 11C-methionine in 45 positron emission tomography-guided stereotactic brain biopsies.
Périodique
Journal of Neurosurgery
Auteur(s)
Pirotte B., Goldman S., Massager N., David P., Wikler D., Lipszyc M., Salmon I., Brotchi J., Levivier M.
ISSN
0022-3085 (Print)
ISSN-L
0022-3085
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
101
Numéro
3
Pages
476-483
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Résumé
OBJECT: The aim of this study was to compare the contribution of the tracers 11C-methionine (Met) and 18F-fluorodeoxy-glucose (FDG) in positron emission tomography (PET)-guided stereotactic brain biopsy.
METHODS: Forty-five patients underwent combined Met-PET and FDG-PET studies associated with computerized tomography (CT)- or magnetic resonance (MR)-guided stereotactic biopsy. Each patient presented with a lesion that was in proximity to the cortical or subcortical gray matter. The Met-PET and FDG-PET scans were analyzed to determine which tracer offers the best information to guide at least one stereotactic biopsy trajectory. Histologically based diagnoses were rendered in all patients (39 tumors, six nontumorous lesions) and biopsies were performed in all tumors with the aid of PET guidance. When tumor FDG uptake was higher than that in the gray matter (18 tumors), FDG was used for target definition. When FDG uptake was absent or equivalent to that in the gray matter (21 tumors), Met was used for target definition. Parallel review of all histological and imaging data showed that all tumors had an area of abnormal Met uptake and 33 had abnormal FDG uptake. All six nontumorous lesions had no Met uptake and biopsies were performed using CT or MR guidance only. All tumor trajectories had an area of abnormal Met uptake; all nondiagnostic trajectories in tumors had no abnormal Met uptake.
CONCLUSIONS: When FDG shows limitations in target selection, Met is a good alternative because of its high specificity in tumors. Moreover, in the context of a single-tracer procedure and regardless of FDG uptake, Met is a better choice for PET guidance in neurosurgical procedures.
Mots-clé
Adolescent, Adult, Aged, Aged, 80 and over, Biopsy, Brain/pathology, Brain/radionuclide imaging, Brain Diseases/pathology, Brain Diseases/radionuclide imaging, Brain Neoplasms/pathology, Brain Neoplasms/radionuclide imaging, Carbon Radioisotopes/diagnostic use, Carbon Radioisotopes/pharmacokinetics, Cerebral Cortex/pathology, Cerebral Cortex/radionuclide imaging, Child, Child, Preschool, Diagnosis, Differential, Energy Metabolism/physiology, Female, Fluorodeoxyglucose F18/diagnostic use, Fluorodeoxyglucose F18/pharmacokinetics, Humans, Image Processing, Computer-Assisted, Male, Methionine/diagnostic use, Methionine/pharmacokinetics, Middle Aged, Neuronavigation, Prognosis, Sensitivity and Specificity, Stereotaxic Techniques, Tomography, Emission-Computed
Pubmed
Web of science
Création de la notice
20/01/2008 18:35
Dernière modification de la notice
03/03/2018 19:00
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