What we would like to know about the antihypertensive mechanisms of angiotensin converting enzyme inhibition

Détails

ID Serval
serval:BIB_86B5DDE08C5D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
What we would like to know about the antihypertensive mechanisms of angiotensin converting enzyme inhibition
Périodique
Journal of Hypertension. Supplement
Auteur(s)
Brunner  H. R., Waeber  B., Nussberger  J.
ISSN
0952-1178 (Print)
Statut éditorial
Publié
Date de publication
12/1988
Volume
6
Numéro
3
Pages
S1-5
Notes
Journal Article
Review --- Old month value: Dec
Résumé
Angiotensin converting enzyme (ACE) inhibitors induce haemodynamic, humoral and metabolic actions which have been well characterized during the last decade. The precise mechanisms involved in these actions still need clarification. Among the many questions we need answered are the following: under steady-state conditions, does plasma ACE activity reflect angiotensin I conversion in tissues? Do the low levels of angiotensin II observed after ACE inhibition still contribute to vascular tone? What is the precise role of extrarenal tissue renin in the regulation of vascular tone? What is the role of bradykinin, prostaglandins and the interaction with the sympathetic nervous system in the antihypertensive effect of ACE inhibition? We hope that definite answers to these questions will be found during the second decade of the use of ACE inhibitors.
Mots-clé
Angiotensin-Converting Enzyme Inhibitors/*pharmacology Animals Blood Pressure/*drug effects Bradykinin/pharmacology Dinoprostone/metabolism Humans Renin-Angiotensin System/drug effects Sympathetic Nervous System/drug effects/physiology
Pubmed
Web of science
Création de la notice
05/03/2008 17:39
Dernière modification de la notice
03/03/2018 19:00
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