Genome-Wide Analysis Reveals Novel Regulators of Growth in Drosophila melanogaster.

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Ressource 1Télécharger: BIB_86B1471396C8.P001.pdf (4716.16 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_86B1471396C8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Genome-Wide Analysis Reveals Novel Regulators of Growth in Drosophila melanogaster.
Périodique
Plos Genetics
Auteur(s)
Vonesch S.C., Lamparter D., Mackay T.F., Bergmann S., Hafen E.
ISSN
1553-7404 (Electronic)
ISSN-L
1553-7390
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
12
Numéro
1
Pages
e1005616
Langue
anglais
Résumé
Organismal size depends on the interplay between genetic and environmental factors. Genome-wide association (GWA) analyses in humans have implied many genes in the control of height but suffer from the inability to control the environment. Genetic analyses in Drosophila have identified conserved signaling pathways controlling size; however, how these pathways control phenotypic diversity is unclear. We performed GWA of size traits using the Drosophila Genetic Reference Panel of inbred, sequenced lines. We find that the top associated variants differ between traits and sexes; do not map to canonical growth pathway genes, but can be linked to these by epistasis analysis; and are enriched for genes and putative enhancers. Performing GWA on well-studied developmental traits under controlled conditions expands our understanding of developmental processes underlying phenotypic diversity.
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/03/2016 19:28
Dernière modification de la notice
08/05/2019 21:27
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