Article: article from journal or magazin.
A new infectious mammary tumor virus in the milk of mice implanted with C4 hyperplastic alveolar nodules.
European Journal of Immunology
We have previously characterized an infectious mouse mammary tumor virus [(MMTV(SW)] which induces a strong superantigen response in vivo. Here we describe the isolation and characterization of MMTV(C4) which was derived from milk of mice implanted with hyperplastic alveolar nodules. MMTV(C4) stimulates V beta 2 expressing T cells after local injection in vivo. Comparison with known open reading frame (orf) sequences revealed high homology to Mtv-6, an endogenous virus interacting with V beta 3-expressing T cells. The carboxyl-terminal amino acids were, however, altered. High homology including the carboxyl-terminal orf amino acids were found with MMTV(C3H-K). We show here that MMTV(C3H-K) has lost its superantigen function. Sequence comparisons permitted the characterization of few key amino acids which could be important for T cell receptor interaction and superantigen processing.
Amino Acid Sequence, Animals, Base Sequence, DNA, Viral/genetics, Female, Hyperplasia, Mammary Glands, Animal/immunology, Mammary Glands, Animal/microbiology, Mammary Neoplasms, Experimental/genetics, Mammary Neoplasms, Experimental/immunology, Mammary Tumor Virus, Mouse/genetics, Mammary Tumor Virus, Mouse/immunology, Mice, Mice, Inbred BALB C, Milk/microbiology, Molecular Sequence Data, Neoplasm Transplantation, Precancerous Conditions/genetics, Precancerous Conditions/immunology, Receptors, Antigen, T-Cell, alpha-beta/genetics, Sequence Deletion, Viral Proteins/genetics
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