Maintenance of radiation-induced intestinal fibrosis: cellular and molecular features.

Details

Serval ID
serval:BIB_86298D2337BB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Maintenance of radiation-induced intestinal fibrosis: cellular and molecular features.
Journal
World journal of gastroenterology
Author(s)
Haydont V., Vozenin-Brotons M.C.
ISSN
1007-9327 (Print)
ISSN-L
1007-9327
Publication state
Published
Issued date
21/05/2007
Peer-reviewed
Oui
Volume
13
Number
19
Pages
2675-2683
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Recent advances in cell and molecular radiobiology clearly showed that tissue response to radiation injury cannot be restricted to a simple cell-killing process, but depends upon continuous and integrated pathogenic processes, involving cell differentiation and crosstalk between the various cellular components of the tissue within the extracellular matrix. Thus, the prior concept of primary cell target in which a single-cell type (whatever it's epithelial or endothelial cells) dictates the whole tissue response to radiation injury has to be replaced by the occurrence of coordinated multicellular response that may either lead to tissue recovery or to sequel development. In this context, the present review will focus on the maintenance of the radiation-induced wound healing and fibrogenic signals triggered by and through the microenvironment toward the mesenchymal cell compartment, and will highlight how sequential and sustained modifications in cell phenotypes will in cascade modify cell-to-cell interactions and tissue composition.

Keywords
Cell Communication, Cell Differentiation/radiation effects, Fibrosis, Humans, Intestines/pathology, Intestines/radiation effects, Mesoderm/pathology, Mesoderm/radiation effects, Radiation Injuries/pathology, Radiotherapy/adverse effects
Pubmed
Web of science
Create date
30/04/2018 14:41
Last modification date
20/08/2019 14:45
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