CERN’s Large Hadron Collider will store an unprecedented amount of energy in its circulating beams. Beam-loss monitoring (BLM) is, therefore, critical for machine protection. It must protect against the consequences (equipment damage, quenches of superconducting magnets) of excessive beam loss. About 4000 monitors will be installed at critical loss locations. Each monitor has 384 beam abort thresholds associated; for 12 integrated loss durations (40μs to 83 s) and 32 energies (450 GeV to 7 TeV). Depending on monitor location, the thresholds vary by orders of magnitude. For simplification, the monitors are grouped in "families". Monitors of one family protect similar magnets against equivalent loss scenarios. Therefore, they are given the same thresholds. The start-up calibration of the BLM system is required to be within a factor of five in accuracy; and the final accuracy should be a factor of two. Simulations (backed-up by control measurements) determine the relation between the BLM signal, the deposited energy and the critical energy deposition for damage or quench (temperature of the coil). The paper presents the strategy of determining 1.5 million threshold values.