Prevalence and Determinants of REM Sleep Behavior Disorder in the General Population.

Détails

ID Serval
serval:BIB_8542A41C4C73
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Prevalence and Determinants of REM Sleep Behavior Disorder in the General Population.
Périodique
Sleep
Auteur(s)
Haba-Rubio J., Frauscher B., Marques-Vidal P., Toriel J., Tobback N., Andries D., Preisig M., Vollenweider P., Postuma R., Heinzer R.
ISSN
1550-9109 (Electronic)
ISSN-L
0161-8105
Statut éditorial
Publié
Date de publication
05/12/2017
Peer-reviewed
Oui
Volume
41
Numéro
2
Pages
UNSP zsx197
Langue
anglais
Notes
Publication types: Journal Article

Résumé
REM sleep behavior disorder (RBD) is a parasomnia associated with neurodegenerative synucleinopathies. Its prevalence is largely unknown. This study determined the prevalence and characteristics of RBD in the general population using gold-standard polysomnography.
Full polysomnographic data from 1997 subjects (age=59±11.1 years, 53.6% women) participating in a population-based study (HypnoLaus, Lausanne, Switzerland) were collected. Sleep-related complaints and habits were investigated using various sleep measures including the Munich Parasomnia Screening (MUPS) questionnaire, which includes two questions evaluating complex motor behaviors suggestive of RBD. Full polysomnography was performed at home. For subjects screening positive for RBD, muscle activity during REM sleep was quantified to diagnose RBD.
368 participants endorsed dream-enactment behavior on either of the two MUPS questions, and 21 fulfilled polysomnographic criteria for RBD, resulting in an estimated prevalence of 1.06% (95% CI=0.61-1.50), with no difference between men and women. Compared to RBD- participants, RBD+ took more frequently antidepressants and antipsychotics (23.8% vs. 5.4%, p=0.005; 14.3% vs. 1.5%, p=0.004, respectively), and were more frequently smokers/ex-smokers (85% vs. 56.6%, p=0.011). On polysomnography, RBD+ had more stage N2 sleep (52±11.5% vs. 46.3±10.2%, p=0.024) and less REM sleep (18±6.4% vs. 21.9±6.2%, p=0.007), lower AHI in REM sleep (3.8±5.2 vs. 8.9±13/h, p=0.035) and lower autonomic arousal index (31±14.9 vs. 42.6±19.5/h, p=0.002).
In our middle-to-older age population-based sample, the prevalence of RBD was 1.06%, with no difference between men and women. RBD was associated with antidepressant and antipsychotic use and with minor differences in sleep structure.

Mots-clé
Polysomnography, REM sleep without atonia, parasomnia, sleep, synucleinopathies
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/12/2017 15:22
Dernière modification de la notice
20/08/2019 14:44
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