How do thyroid hormone receptors bind to structurally diverse response elements?

Détails

ID Serval
serval:BIB_853BB9502A6E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
How do thyroid hormone receptors bind to structurally diverse response elements?
Périodique
Molecular and Cellular Endocrinology
Auteur(s)
Desvergne B.
ISSN
0303-7207[print], 0303-7207[linking]
Statut éditorial
Publié
Date de publication
04/1994
Volume
100
Numéro
1-2
Pages
125-131
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Three classes of thyroid hormone response elements have been described. They are composed of two half-sites arranged either as a palindromic, a direct repeat or as an inverted palindromic array. Receptor homodimers as well as heterodimers can bind to all three types of response element. While the ligand binding domain of the receptors provides the major dimerization surface, asymmetric contacts between the DNA binding domains are necessary for binding to a direct repeat. Moreover, some recent findings suggest that in TR, compared to RXR, the ligand binding domain has a 180 degrees rotation with respect to the DNA binding domain. This feature could explain the preferential binding of the RXR-TR heterodimer to the direct repeat response element, in which RXR exclusively binds the 5' half-site, and of the TR homodimer to the inverted palindrome response element.
Mots-clé
Amino Acid Sequence, Animals, Base Sequence, Binding Sites, Consensus Sequence, DNA/metabolism, DNA-Binding Proteins/metabolism, Ligands, Models, Molecular, Molecular Sequence Data, Molecular Structure, Nucleic Acid Conformation, Promoter Regions, Genetic, Protein Binding, Protein Conformation, Receptors, Thyroid Hormone/metabolism, Regulatory Sequences, Nucleic Acid, Repetitive Sequences, Nucleic Acid, Transcription Factors/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 16:27
Dernière modification de la notice
03/03/2018 18:56
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