Gènes, environnement et neurodéveloppement: te cas de la schizophrénie [Schizophrenia: genes, environment and neurodevelopment].

Détails

Ressource 1Demande d'une copie Sous embargo indéterminé.
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_850D9FB61CA5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Gènes, environnement et neurodéveloppement: te cas de la schizophrénie [Schizophrenia: genes, environment and neurodevelopment].
Périodique
Revue Médicale Suisse
Auteur(s)
Do K.Q.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
9
Numéro
398
Pages
1672, 1674-1672, 1677
Langue
français
Notes
Publication types: English Abstract ; Journal ArticlePublication Status: ppublish
Résumé
Psychoses are complex diseases resulting from the interaction between genetic vulnerability factors and various environmental risk factors during the brain development and leading to the emergence of the clinical phenotype at the end of adolescence. Among the mechanisms involved, a redox imbalance plays an important role, inducing oxidative stress damaging to developing neurons. As a consequence, the excitatory/inhibitory balance in cortex and the pathways connecting brain areas are both impaired. Childhood and adolescence appear as critical periods of vulnerability for deleterious environmental insults. Antioxidants, applied during the environmental impacts, should allow preventing these impairments as well as their clinical consequences.
Pubmed
Création de la notice
01/11/2013 11:16
Dernière modification de la notice
03/03/2018 18:56
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